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. Author manuscript; available in PMC: 2015 Nov 8.
Published in final edited form as: Toxicol Pathol. 2013 Jul 11;42(3):582–590. doi: 10.1177/0192623313493689

Figure 1.

Figure 1

Classification of histopathologic alterations in respiratory epithelium. Images are from tracheas of rats inhaling 356 ppm in a previous study (Hubbs et al. 2008) and the rat nose from a high-dose animal in this study. (A) Intact respiratory epithelium in a diacetyl-exposed rat trachea. (B) Attenuated epithelium (solid arrow) in the diacetyl-exposed trachea may represent an attempt at sliding repair of denuded epithelium (dashed arrow). (C) Tracheal epithelial necrosis with detachment. (D) Respiratory epithelial detachment (solid arrow) and denuded basement membrane (dashed arrow) in the nose of a rat in the high-dose group from the current study. Hematoxylin and eosin stain; bar = 20 μm.