Skip to main content
. Author manuscript; available in PMC: 2016 Nov 15.
Published in final edited form as: J Immunol. 2015 Oct 9;195(10):5055–5065. doi: 10.4049/jimmunol.1501158

Figure 6. Depletion of macrophages significantly reduces WGP β-glucan-mediated therapeutic efficacy.

Figure 6

Groups of C57Bl/6 mice (n=6–8) were injected intravenously with 100 µl Clodronate (5mg/ml) one day prior to LLC subcutaneous inoculation. Mice were then injected with Clodronate weekly during the experiment. Mice without Clodronate injection were used as controls. When the tumor sizes reached 5 mm in diameter, mice were treated with WGP β-glucan or control PBS daily via oral gavage. Tumor diameters were measured every other day and mice were euthanized when tumors reached 15 mm in diameter. * P<0.05, ** P<0.01, *** P<0.001, **** P<0.0001.