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. Author manuscript; available in PMC: 2016 Nov 15.
Published in final edited form as: J Immunol. 2015 Oct 2;195(10):4884–4891. doi: 10.4049/jimmunol.1501194

Figure 2. Increased turnover of blood monocytes in SIV-infected macaques is not reflected in the BAL.

Figure 2

BAL samples were collected prior to and during different stages of SIV infection from rhesus macaques. BrdU or EdU was injected i.v. into SIV-infected rhesus macaques and the turnover of blood monocytes and AM recovered from BAL was analyzed by flow cytometry. There was no statistically significant correlation between blood monocyte turnover and AM turnover at 24 hr after BrdU/EdU injection (A: n= 21), 48 hr (B: n=12) and 7 days later (C: n=38) using Spearman’s correlation analysis. There also was no difference in the percent of macrophages recovered in BAL from SIV-infected vs uninfected macaques (D) although there was a significant decrease in the absolute number of macrophages recovered from BAL of SIV-infected compared to uninfected macaques by Student’s t test (E). The numbers of macrophages recovered from BAL of SIV-infected monkeys did not correlate with blood monocyte turnover by Spearman’s correlation analysis (F).