Reduced frequency of proliferating CD4+ T cells, lower interferon-γ (IFNγ) secreting TH1 (but not IL-17 secreting TH17) and follicular T helper (Tfh) cells in Sle123→ApoA-Itg mice. (A) Flow cytometric analysis of in vivo BrdU incorporation into lymph node CD4+ T cells 6 hours following IP BrdU injection (n=8) (‡p<0.05 by T test compared to control non-BMT, *p<0.05 by one way ANOVA within control, control WT BMT or Sle123 BMT groups). (B) Numbers of IFNγ secreting and IL-17 secreting CD4+ T cells in lymph nodes from the indicated 38 week old mice (representative flow cytometric plots shown alongside). (C) CXCR5+PD-1+BCL-6+ follicular T helper (Tfh) cells and (D) CD19+CD95+PNA+ germinal center B (GC B) cells in 38 week old WT, WT→WT, Sle123→WT, Sle123→ApoA-I−/− and Sle123→ApoA-Itg mice. (n=6) (All data mean ± SD, ‡p<0.05 by one way ANOVA compared to WT and WT→WT control groups, *p<0.05 by one way ANOVA within Sle123 BMT group).