Table II.
Lipid profiles in control, control WT BMT and Sle123 BMT WT, ApoA-I−/− and ApoA-Itg mice (38 weeks of age) (n=8).
| WT | ApoA-I−/− | ApoA-Itg | WT → WT |
WT → ApoA-I−/− |
WT → ApoA-Itg |
Sle123 → WT |
Sle123 → ApoA-I−/− |
Sle123 → ApoA-Itg |
|
|---|---|---|---|---|---|---|---|---|---|
|
HDL-C (mg/dl) |
78.6 ±8.9 |
26.5 ±7.1‡ |
159.5 ±22.6‡ |
69.4 ±8.6 |
22.8 ±4.4‡ |
181.4 ±35.0‡ |
62.6 ±7.7* |
28.7 ±6.1‡ |
167.2 ±22.7‡ |
|
LDL-C (mg/dl) |
30.5 ±7.2 |
19.6 ±5.1 |
143.1 ±51.5‡* |
29.2 ±6.8 |
12.5 ±2.1 |
62.1 ±27.9‡ |
23.6 ±4.7 |
26.5 ±19.4 |
50.8 ±16.8‡ |
|
TG (mg/dl) |
24.7 ±11.1 |
27.9 ±15.3 |
72.5 ±24.0‡ |
36.4 ±10.6 |
26.8 ±5.9 |
46.7 ±30.0 |
38.8 ±50.4 |
25.0 ±13.3 |
62.5 ±20.8‡ |
|
FFA (mg/dl) |
24.2 ±6.2 |
19.6 ±2.6 |
33.0 ±8.6 |
28.0 ±6.2 |
15.5 ±6.4 |
20.3 ±6.0 |
27.5 ±10.2 |
20.8 ±4.7 |
22.2 ±6.3 |
|
PON-1 (nmol/min/ml) |
153.3 ±34.3 |
39.6 ±9.0‡ |
222.6 ±22.8‡ |
164.3 ±10.6 |
62.2 ±17.6‡ |
338.7 ±82.7‡* |
110.9 ±28.3* |
47.6 ±15.2‡ |
209.2 ±53.1‡ |
HDL-C = high-density lipoprotein cholesterol; LDL-C = low-density lipoprotein cholesterol; TG = triglycerides; FFA = free fatty acids; PON-1=paraoxonase-1. Values are the mean ± SD.
*
p<0.05 (One Way ANOVA) within the same host genotype group (WT, ApoA-I−/− or ApoA-Itg).
‡
p<0.05 (One Way ANOVA) within the same control non-BMT, control WT BMT or Sle123 BMT group.