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. Author manuscript; available in PMC: 2017 Jul 1.
Published in final edited form as: Mol Neurobiol. 2015 May 8;53(5):2983–2994. doi: 10.1007/s12035-015-9179-1

Figure 5.

Figure 5

Effect of iNOS and NADPH oxidase inhibition/genetic ablation on Maneb- and paraquat-induced protein radical formation in the nigrostriatal tissue of mice after 6 weeks of Maneb and paraquat coexposure. (A) Anti-DMPO ELISA showing protein radical formation in Maneb and paraquat (MP) coexposed mice with or without pretreatment with FeTPPS (10mg/kg, i.p.), apocynin (10mg/kg, i.p.), or 1400W (15 mg/kg, i.p.), and in p47 phox or iNOS knockout mice. (B) Anti-DMPO Western blotting of immunoprecipitated alpha-synuclein from the nigrostriatal tissue of all experimental groups as in Figure A. Data show mean values ± SEM from four independent experiments (n=4). (*P<0.05, ** P<0.01, *** P<0.001, with respect to control, and ## P<0.01, ### P<0.001, with respect to the Maneb and paraquat coexposed group.)