Table 1. miR-17-92 cluster overexpression in lymphoproliferative disorders.
Disease | miR-17-92 dysregulation | Genomic aberrations | References |
---|---|---|---|
DLBCL | overexpression | 13q31.3 amplification; MYC aberration in complex karyotypes | [17]; [26]; [57]; [58]; [59]; [61]; [62]; [64]; [65]; [56] |
MCL | overexpression | 13q31.3 amplification | [24] |
BL | overexpression | 13q31.3 amplification; MYC translocation | [77]; [78]; [79]; [80];[81]; [82] |
CLL | overexpression upon microenvironmental stimuli compared to the unstimulated counterpart | absence of associated genomic aberrations | [22]; [94] |
Abbreviations: DLBCL, diffuse large B cell lymphoma; MCL, mantle cell lymphoma; BL, Burkitt's lymphoma; CLL, chronic lymphocytic leukemia.