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. 2015 Apr 10;6(23):19456–19468. doi: 10.18632/oncotarget.3318

Figure 5. miR-34a, miR-34c, miR-369-3p, miR-374a, and miR-4524a/b suppress glycolysis and tumorigenesis.

Figure 5

(A, B, C) lactate (in the culture media) (A), Glucose (in the culture media) (B), and intracellular ATP levels (B) in human CRC cell lines stably expressing LDHA-shRNA and scramble-shRNA. (D, E, F) lactate (in the culture media) (D), Glucose (in the culture media) (E), and intracellular ATP levels (F) in human CRC cell lines stably expressing indicated miRNAs or scramble cells lines. (G–J) Tumor formation assay results. 6 × 106 HCT116 or HCT15 cells with indicated expression conditions were injected subcutaneously into 6 week-old nude mice (n = 8 mice/group). After four weeks, the mice were sacrificed, and the tumors were resected, weighed and imaged. Tumor photos, and tumor weight of HCT116 (G, H) or HCT15 (I, J) cells stably expressing indicated miRNAs or scramble cells. Data represent mean ± SD. *0.01 < p < 0.05; **0.001 < p < 0.01.