Table 1. Exome sequencing of BCSCs, non-BCSCs, NBBCs and non-NBBCs.

BCSCs	CHROM	POS	REF	ALT	QUAL	FILTER	Func	Gene	ExonicFunc	cytoband
	4	1807894	G	T	7514.77	PASS	exonic	FGFR3	nonsynonymous SNV	4p16.3
	5	1255520	G	A	2957.77	PASS	exonic	TERT	nonsynonymous SNV	5p15.33
	12	25362217	A	G	113.9	PASS	UTR3	KRAS	.	12p12.1
	12	25368462	C	G	3109.77	PASS	exonic	KRAS	nonsynonymous SNV	12p12.1
	12	25388290	G	T	31.74	PASS	intronic	KRAS	.	12p12.1
	13	48919358	T	G	764.77	PASS	intronic	RB1	.	13q14.2
	13	48947469	G	T	539.77	PASS	intronic	RB1	.	13q14.2
	13	49027140	A	C	150.77	PASS	exonic	RB1	nonsynonymous SNV	13q14.2
	13	49051012	C	T	2518.77	PASS	intronic	RB1	.	13q14.2
	16	3781313	G	G	6740.77	PASS	exonic	CREBBP	nonsynonymous SNV	16p13.3
	16	3811556	A	G	15232.77	PASS	intronic	CREBBP	.	16p13.3
	16	3811596	C	T	8497.77	PASS	intronic	CREBBP	.	16p13.3
	22	41513175	T	C	281.77	PASS	intronic	EP300	.	22q13.2
	22	41537234	G	T	1184.77	PASS	intronic	EP300	.	22q13.2
	22	41543983	C	G	2608.77	PASS	intronic	EP300	.	22q13.2
	22	41551039	T	A	10641.77	PASS	exonic	EP300	synonymous SNV	22q13.2
	22	41553259	G	T	565.77	PASS	exonic	EP300	nonsynonymous SNV	22q13.2
non-BCSCs	CHROM	POS	REF	ALT	QUAL	FILTER	Func	Gene	ExonicFunc	cytoband
	4	1807894	G	T	19732.77	PASS	exonic	FGFR3	nonsynonymous SNV	4p16.3
	12	25362217	A	G	54.28	PASS	UTR3	KRAS	.	12p12.1
	12	25368462	C	A	279.78	PASS	exonic	KRAS	nonsynonymous SNV	12p12.1
	13	49051012	C	T	210.78	PASS	intronic	RB1	.	13q14.2
	16	3811556	A	G	5398.77	PASS	intronic	CREBBP	.	16p13.3
	16	3811596	C	T	2659.77	PASS	intronic	CREBBP	.	16p13.3
	16	3828847	C	CT	33.73	PASS	intronic	CREBBP	.	16p13.3
	22	41513175	T	C	153.77	PASS	intronic	EP300	.	22q13.2
	22	41537234	G	T	198.78	PASS	intronic	EP300	.	22q13.2
	22	41543983	C	G	636.77	PASS	intronic	EP300	.	22q13.2
	22	41553259	G	A	214.77	PASS	exonic	EP300	synonymous SNV	22q13.2
NBBCs	CHROM	POS	REF	ALT	QUAL	FILTER	Func	Gene	ExonicFunc	cytoband
	12	25368462	C	T	161.84	PASS	exonic	KRAS	.	12p12.1
	12	25388290	G	T	35.74	PASS	intronic	KRAS	synonymous SNV	12p12.1
	13	48919358	T	G	83.28	PASS	intronic	RB1	.	13q14.2
	13	48947469	G	T	112.9	PASS	intronic	RB1	.	13q14.2
	16	3811556	A	G	5016.77	PASS	intronic	CREBBP	.	16p13.3
	22	41537234	G	T	285.77	PASS	intronic	EP300	.	22q13.2
	22	41543983	C	G	671.77	PASS	intronic	EP300	.	22q13.2
non-NBBCs	CHROM	POS	REF	ALT	QUAL	FILTER	Func	Gene	ExonicFunc	cytoband
	12	25368462	C	T	161.84	PASS	exonic	KRAS	.	12p12.1
	12	25388290	G	T	35.74	PASS	intronic	KRAS	synonymous SNV	12p12.1
	13	48947469	G	T	112.9	PASS	intronic	RB1	.	13q14.2
	16	3811556	A	G	5016.77	PASS	intronic	CREBBP	.	16p13.3
	22	41543983	C	G	671.77	PASS	intronic	EP300	.	22q13.2