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. 2015 Apr 17;6(23):19605–19618. doi: 10.18632/oncotarget.3747

Figure 3. TS-induced EMT is associated with suppression of ERK5 activation in normal human bronchial epithelial (NHBE) cells.

Figure 3

A. Cigarette smoke extract (CSE) inhibited ERK5 activation in NHBE cells. The levels of phosphorylated ERK5, the active form of ERK5, as well as total ERK5, were measured by Western blotting following CSE treatment. B. CSE increased AP-1 protein activation, as shown by elevated levels of phosphorylated c-Fos and phosphorylated c-Jun. Glyceraldehyde 3-phosphate dehydrogenase was used as loading control.