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. 2015 Apr 17;6(23):19605–19618. doi: 10.18632/oncotarget.3747

Figure 7. TS induces alterations in EMT markers' expression and ERK5 inhibition in the lungs of mice exposed to TS for 12 weeks.

Figure 7

A. TS decreased the protein levels of E-cadherin and ZO-1, and increased the protein levels of Vimentin and N-cadherin in the lungs of mice, as shown by. Western blotting. B. TS reduced mRNA levels of E-cadherin and ZO-1, and induced mRNA levels of Vimentin and N-cadherin in the lungs, detected by quantitative reverse transcriptase–polymerase chain reaction. C. TS inhibited ERK5 activation in mouse lungs shown by Western blot analysis of phosphorylated ERK5. D. TS elevated levels of phosphorylated c-Fos and phosphorylated c-Jun as assesed by Western blotting. Data are expressed as mean ± SD. **P < 0.01, compared with FA control group. FA = filtered air; TS = tobacco smoke.