Figure 6. BTG1 suppresses the growth and lung metastasis of gastric cancer cells.
The growth of BGC-823 cells was faster than their BTG1 tranfectants by gross appearance A. CT scanning B. and measuring tumor volume (C, p < 0.05). BGC-823 cells showed more lung metastasis foci and heavier lung weight than their BTG1 transfectants by gross observation D. mandelic acid staining E. contrast CT scanning F. number counting (G, p < 0.05) and weighting (H, p < 0.05). The transfectant cells showed stronger expression of BTG1 I. ki-67 J. and LC-3B K. than the control in subcutaneous tumor and lung metastatic foci. The apoptotic level was higher in BTG1 tranfectants than maternal cells by TUNEL assay L. *p < 0.05, compared with the transfectant.