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. 2015 Apr 14;6(23):19721–19734. doi: 10.18632/oncotarget.3821

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Copyright: © 2015 Choi et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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(A) p27 (VP→AA) was resistant to COP1-meditated degradation. 293T cells were co-transfected with the indicated plasmids. Cell lysates were analyzed by immunoblotting with anti-p130, anti-Flag-p27, anti-GFP-COP1, or Actin antibodies. (B) p27 (VP→AA) diminished COP1-mediated cell cycle progression better than wt p27. 293T cells were co-transfected with the indicated plasmids as shown in A. Cells were analyzed for cell-cycle distribution using fluorescence-activated cell sorting.