Table 1. The effect of thiopental sodium on claw pain threshold in intact and adrenalectomized rats.
Groups | Pain threshold (g) | P* | Algesia (%) | Analgesia (%) | |
---|---|---|---|---|---|
Before drugs | After drugs | ||||
TS (n=10) | 26.1 ± 1.2 | 19 ± 1.2 | <0.05 | 27.2 | |
ATS (n=10) | 24.3 ± 1.4 | 39.8 ± 2.2 | <0.01 | - | 39 |
ADR (n=10) | 24.8 ± 4.9 | 39.1 ± 2.2 | <0.01 | - | 36.6 |
A-TS (n=10) | 18.3 ± 2.5 | 16.8 ± 2.6 | >0.05 | 20.1 | - |
A-ATS (n=10) | 19.5 ± 0.9 | 34.2 ± 1.3 | <0.01 | - | 43 |
A-ADR (n=10) | 16.3 ± 2.4 | 28 ± 2.5 | <0.01 | - | 41.8 |
The paired t-test test was performed. TS, intact groups receiving 15 mg/kg thiopental sodium, ATS, intact groups receiving 0.3 mg/kg adrenaline + 15 mg/kg thiopental sodium, ADR, intact groups receiving 0.3 mg/kg Adrenaline; A-TS, adrenalectomized groups receiving 15 mg/kg thiopental sodium, A-ATS, adrenalectomized groups receiving 0.3 mg/kg Adrenaline + 15 mg/kg thiopental sodium, A-ADR, adrenalectomized groups receiving 0.3 mg/kg adrenaline; n, number of animals. * P ≤ 0.05 was significant.