Down-regulation of ABCE1 inhibited H69/ADR cell proliferation, increased cell inhibitory rate, and promoted H69/ADR cell apoptosis. After tranfected with ABCE1-siRNA, the mRNA and protein expression of ABCE1 in H69/ADR cells was detected using qRT-PCR (A) and Western blot (B). Knocked down the expression of ABCE1 suppressed H69/ADR cell proliferation (C), and increased cell inhibitory rate (D). H69/ADR cell apoptosis rate was promoted after tranfected with ABCE1-siRNA (E, F).