Table 1.
Concentrations of doxorubicin used at each selection dose
| Dose | Doxorubicin |
|---|---|
| IC50 | 0.94 μM |
| Dose 1 | 0.94 nM |
| Dose 2 | 2.82 nM |
| Dose 3 | 8.46 nM |
| Dose 4 | 25.38 nM |
| Dose 5 | 76.14 nM |
| Dose 6 | 228.42 nM |
| Dose 7 | 685.26 nM |
| Dose 8 | 2.06 μM |
| Dose 9 | 6.17 μM |
| Dose 10 | 9.25 μM |
| Dose 11* | 13.88 μM |
H69 lung cancer cells were exposed to progressively higher concentrations (doses) of doxorubicin drugs, beginning at a dose equivalent to 1/1000th of the concentration required to kill or inhibit the growth of 50% of wild-type H69 cells (the IC50). The symbol
*
denotes the highest concentration of drug at which the cells could survive (the maximally tolerated dose).