Table 4.
TNKS1 SNP genotypes between ADC patients and controls
| Genotypes | ADC Controls | p value | OR (95% CI) | M ADC M Controls | p value | OR (95% CI) | F ADC F Controls | p value | OR (95% CI) | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
|
|
||||||||||
| N=331 n (%) | N=500 n (%) | N=189 n (%) | N=259 n (%) | N=142 n (%) | N=240 n (%) | |||||||
| rs12541709 | ||||||||||||
| CC | 128 (38.7) | 229 (45.8) | 76 (40.2) | 120 (46.3) | 52 (36.6) | 108 (45.0) | ||||||
| GG | 38 (11.5) | 55 (11.0) | 23 (12.2) | 35 (13.5) | 15 (10.6) | 20 (8.3) | ||||||
| CG | 165 (49.8) | 216 (43.2) | 0.12 | 90 (47.6) | 104 (40.2) | 0.27 | 75 (52.8) | 112 (46.7) | 0.26 | |||
| GG+CG | 203 (61.3) | 271 (54.2) | 0.04 | 0.75 (0.56-0.99) | 113 (59.8) | 139 (53.7) | 0.20 | 0.78 (0.53-1.14) | 90 (63.4) | 132 (55.0) | 0.11 | 0.76 (0.46-1.08) |
| rs7015700 | ||||||||||||
| GG | 167 (50.5) | 236 (47.2) | 99 (52.4) | 109 (42.1) | 68 (47.9) | 126 (52.5) | ||||||
| AA | 26 (7.9) | 42 (8.4) | 12 (6.3) | 20 (7.7) | 14 (9.9) | 22 (9.2) | ||||||
| AG | 138 (41.7) | 222 (44.4) | 0.66 | 78 (41.3) | 130 (50.2) | 0.09 | 60 (42.3) | 92 (38.3) | 0.68 | |||
| AA+AG | 164 (49.5) | 264 (52.8) | 0.36 | 1.14 (0.86-1.50) | 90 (47.6) | 150 (57.9) | 0.03 | 1.51 (1.04-2.21) | 74 (52.1) | 114 (47.5) | 0.38 | 0.83 (0.55-1.26) |
| rs11991621 | ||||||||||||
| CC | 180 (54.4) | 265 (53.0) | 94 (49.7) | 148 (57.1) | 86 (60.6) | 116 (48.3) | ||||||
| TT | 22 (6.6) | 28 (5.6) | 15 (7.9) | 12 (4.6) | 7 (4.9) | 16 (6.7) | ||||||
| CT | 129 (39.0) | 207 (41.4) | 0.70 | 80 (42.3) | 99 (38.2) | 0.17 | 49 (34.5) | 108 (45.0) | 0.07 | |||
| TT+CT | 151 (45.6) | 235 (47.0) | 0.70 | 1.06 (0.80-1.40) | 95 (50.3) | 111 (42.9) | 0.12 | 0.74 (0.51-1.08) | 56 (39.4) | 124 (51.7) | 0.02 | 1.64 (1.08-2.50) |
| rs6601328 | ||||||||||||
| AA | 187 (56.5) | 284 (56.8) | 114 (60.3) | 133 (51.4) | 73 (51.4) | 150 (62.5) | ||||||
| GG | 17 (5.1) | 24 (4.8) | 8 (4.2) | 13 (5.0) | 9 (6.3) | 11 (4.6) | ||||||
| AG | 127 (38.4) | 192 (38.4) | 0.98 | 67 (35.4) | 113 (43.6) | 0.17 | 60 (42.3) | 79 (32.9) | 0.10 | |||
| GG+AG | 144 (43.5) | 216 (43.2) | 0.93 | 0.99 (0.75-1.31) | 75 (39.7) | 126 (48.6) | 0.06 | 1.44 (0.99-2.11) | 69 (48.6) | 90 (37.5) | 0.03 | 0.64 (0.42-0.97) |
| rs10503380 | ||||||||||||
| GG | 145 (43.8) | 197 (39.4) | 76 (40.2) | 110 (42.5) | 69 (48.6) | 86 (35.8) | ||||||
| AA | 43 (13.0) | 59 (11.8) | 24 (12.7) | 33 (12.7) | 19 (13.4) | 26 (10.8) | ||||||
| AG | 143 (43.2) | 244 (48.8) | 0.29 | 89 (47.1) | 116 (44.8) | 0.88 | 54 (38.0) | 128 (53.3) | 0.01 | |||
| AA+AG | 186 (56.2) | 303 (60.6) | 0.21 | 1.20 (0.91-1.59) | 113 (59.8) | 149 (57.5) | 0.63 | 0.91 (0.62-1.33) | 73 (51.4) | 154 (64.2) | 0.01 | 1.69 (1.11-2.58) |