Figure 4.

The effects of epigenetic drugs on cell proliferation, cell cycle, cell migration and invasion. Cells proliferation was inhibited by 5-Aza or PBA treatment in 786-O (A) and ACHN (E) cells. Cell cycle was arrested at S phase in 786-O (B) and ACHN (F) cells after 5-Aza or PBA treatment. Cell migration was repressed by 5-Aza or PBA treatment in 786-O (C) and ACHN (G) cells. Cells invasive ability was reduced by 5-Aza or PBA treatment in 786-O (D) and ACHN (H) cells. Data are presented by means ± s.d, *P<0.05, **P<0.01, ***P<0.001 vs. control.