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. 2015 Sep 1;8(9):11033–11041.

Table 2.

Univariate analysis and multivariate analysis of the prognostic factors on OS in patients with total SCLC

Factors Univariate analysis Multivariate analysis


MST (m) 2-y OS (%) 3-y OS (%) P HR 95% CI P
Gender
    Male 17 33.5 19.1
    Female 22 46.2 38.8 0.077
Age (years)
    65-70 19.7 43.0 25.9 0.296
    ≥ 70 17.0 31.4 22.3
KPS
    ≥ 80 17.2 40.1 25.2
    < 80 17.3 34.6 20.0 0.092
Wight loss
    < 5% 17.7 37.1 22.7
    ≥ 5% 13.0 28.1 19.0 0.166
Smoking
    Yes 17.0 37.5 22.9
    No 17.9 33.7 20.5 0.888
Cycle of ChT
    < 4 11.0 13.5 4.5 0.301-
    ≥ 4 20.7 45.1 29.2 < 0.001 0.486 0.786 0.003
Pleural effuion
    Yes 14.0 30.0 12.3
    No 17.9 37.7 23.8 0.251
Disease extent
    LS 22.0 45.0 30.5 2.022-
    ES 13.4 26.5 13.7 < 0.001 3.034 4.552 < 0.001
Obstructive
Pneuontise
    Yes 14.0 32.2 20.1
    No 19.0 39.6 24.6 0.082
NSE (ng/mL)
    ≥ 17 17.0 32.1 18.9 0.642-
    < 17 26.0 50.4 34.4 0.003 1.111 1.924 0.706
CEA (ng/mL)
    ≥ 3.4 17.0 33.5 22.4
    < 3.4 17.4 42.8 23.9 0.552

OS, overall survival; SCLC, small cell lung cancer; KPS, Karnofsky performance status; ChT, chemotherapy; LS, limited-stage; ES, extensive-stage; NSE, neuron-specific enolase; CEA, carcinoembryonic antigen.