Table 4.

Correlation analysis of YAP and phospho-YAP expression according to tumor cell compartment with primary and metastatic breast cancer according to metastatic site

Parameter	Total		Bone metastasis		Brain metastasis		Liver metastasis		Lung metastasis
	N = 32 (%)	P-value	N = 7 (%)	P-value	n= 7 (%)	P-value	N = 2 (%)	P-value	N = 16 (%)	P-value
YAP (cytoplasmic)		1.000		0.500		1.000		n/a		1.000
(+) → (+)	4 (12.5)		0 (0.0)		1 (14.3)		0 (0.0)		3 (18.8)
(+) → (-)	5 (15.6)		0 (0.0)		2 (28.6)		0 (0.0)		3 (18.8)
(-) → (+)	6 (18.8)		2 (28.6)		1 (14.3)		0 (0.0)		3 (18.8)
(-) → (-)	17 (53.1)		5 (71.4)		3 (42.9)		2 (100.0)		7 (43.8)
YAP (nuclear)		1.000		n/a		1.000		n/a		n/a
(+) → (+)	0 (0.0)		0 (0.0)		0 (0.0)		0 (0.0)		0 (0.0)
(+) → (-)	0 (0.0)		0 (0.0)		0 (0.0)		0 (0.0)		0 (0.0)
(-) → (+)	1 (3.1)		0 (0.0)		1 (14.3)		0 (0.0)		0 (0.0)
(-) → (-)	31 (96.9)		7 (100.0)		6 (85.7)		2 (100.0)		16 (100.0)
pYAP (cytoplasmic)		1.000		n/a		1.000		n/a		1.000
(+) → (+)	2 (6.2)		0 (0.0)		1 (14.3)		0 (0.0)		1 (6.2)
(+) → (-)	3 (9.4)		0 (0.0)		1 (14.3)		0 (0.0)		2 (12.5)
(-) → (+)	2 (6.2)		0 (0.0)		0 (0.0)		0 (0.0)		2 (12.5)
(-) → (-)	25 (78.1)		7 (100.0)		5 (71.4)		2 (100.0)		11 (68.8)
pYAP (nuclear)		0.500		n/a		0.500		n/a		n/a
(+) → (+)	0 (0.0)		0 (0.0)		0 (0.0)		0 (0.0)		0 (0.0)
(+) → (-)	0 (0.0)		0 (0.0)		0 (0.0)		0 (0.0)		0 (0.0)
(-) → (+)	2 (6.2)		0 (0.0)		2 (28.6)		0 (0.0)		0 (0.0)
(-) → (-)	30 (93.8)		7 (100.0)		5 (71.4)		2 (100.0)		16 (100.0)