Table 2.
Expression of ZEB1, E-cadherin, N-cadherin and β-catenin in primary cervical squamous cell carcinoma and their association with the clinicopathologic characters
| No. of cases | ZEB1 | ZEB1 | N-cadherin | β-catenin | |||||
|---|---|---|---|---|---|---|---|---|---|
|
|
|||||||||
| Variable | 81 | Negative (No.) 44 | Positive (No.) 37 | Loss (No.) 28 | Normal (No.) 53 | Negative (No.) 58 | Positive (No.) 23 | Loss (No.) 16 | Normal (No.) 65 |
| Differentiation | |||||||||
| Well | 14 | 14 | 0 | 0 | 14 | 14 | 0 | 0 | 14 |
| Moderate | 51 | 27 | 24 | 13 | 38 | 42 | 9 | 4 | 47 |
| Poor | 16 | 3 | 13 | 15 | 1 | 2 | 14 | 12 | 4 |
| P-value | 0.000* | 0.000* | 0.000* | 0.000* | |||||
| FIGO stage | |||||||||
| IA | 3 | 3 | 0 | 0 | 3 | 3 | 0 | 0 | 3 |
| IB | 32 | 19 | 13 | 9 | 23 | 26 | 6 | 4 | 28 |
| IIA | 25 | 13 | 12 | 13 | 12 | 14 | 11 | 8 | 17 |
| IIB | 20 | 8 | 12 | 6 | 14 | 14 | 6 | 4 | 16 |
| III | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 |
| IV | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| P-value | 0.255 | 0.187 | 0.200 | 0.330 | |||||
| Invasive depth | |||||||||
| ≤nva | 36 | 19 | 17 | 13 | 23 | 25 | 11 | 8 | 28 |
| >1/2 | 45 | 25 | 20 | 15 | 30 | 33 | 12 | 8 | 37 |
| P-value | |||||||||
| Vascular invasion | |||||||||
| Negative | 49 | 35 | 14 | 12 | 37 | 36 | 13 | 6 | 43 |
| Positive | 32 | 11 | 21 | 17 | 15 | 19 | 13 | 10 | 22 |
| P-value | 0.001* | 0.009* | 0.187 | 0.037* | |||||
| Lymph node | |||||||||
| Negative | 47 | 32 | 15 | 13 | 34 | 35 | 12 | 9 | 38 |
| Positive | 34 | 12 | 22 | 15 | 19 | 23 | 11 | 7 | 27 |
| P-value | 0.004* | 0.127 | 0.608 | 0.715 | |||||
*
P < 0.05 was regarded as statistically significant.