Table 5.

The correlation of Caspase and Ki-67 immunoexpressions with Grade, Stage, Lymphovascular Involvement and Perineural Infiltration

		Grade I	Grade II	Grade III	p	T1	T2	T3	T4	p	N0	N1	N2	N3	p	LVI (-)	LVI (+)	p	PI (-)	PI (+)	p
Ki67 TM%	Mean ± SD	4.38 ± 3.85	5.16 ± 6.13	9.13 ± 9.31	0.123	5.63 ± 6.89	7.24 ± 8.42	3.86 ± 1.41	6.05 ± 5.59	0.790	6.75 ± 6.89	8.58 ± 10.33	4.31 ± 3.41	2.8 ± 1.79	0.710	6.56 ± 6.6	6.53 ± 7.88	0.681	7.34 ± 8.17	4.3 ± 4.27	0.278
	Mean (IQR)	2.5 (1.38-8.25)	3 (1-7)	4.75 (2.1-14.13)		2.4 (1-9.75)	3.2 (1.3-11.25)	4.5 (2.4-5)	6.05 (1.58-8)		4 (1-11)	3.1 (1.43-16)	3 (1.4-7)	3 (1-4.5)		4 (1.5-10.5)	3 (1.05-9.25)		4 (1.5-11)	2.55 (1-7.75)
Ki67 TP%	Mean ± SD	4.7 ± 3.32	7.96 ± 10.26	8.55 ± 9.06	0.892	8.23 ± 11.53	7.52 ± 7.97	3.2 ± 1.64	8.5 ± 7.78	0.803	7.02 ± 6.52	10.69 ± 14.04	7.29 ± 7.45	3.5 ± 2.45	0.792	7.62 ± 7.44	7.73 ± 9.8	0.638	8.6 ± 9.96	5.15 ± 5.25	0.277
	Mean (IQR)	4 (1.4-8.5)	4 (2-9)	4 (1.25-16)		4 (1.25-9)	4 (1.5-11)	4 (1.5-4.5)	8.5 (2.25-11)		4 (2-11)	2.8 (2-19)	5 (1-14)	4 (1-5.75)		6.5 (1.5-9)	3 (2-11)		4 (2-11)	3 (1-7.25)
Caspase TM%	Mean ± SD	1.88 ± 1.55	1.77 ± 1.27	2.56 ± 2.02	0.321	1.89 ± 1.41	2.16 ± 1.85	2.1 ± 1.67	3 ± 0	0.510	1.95 ± 1.34	2.72 ± 2.4	1.77 ± 1.22	1.44 ± 0.44	0.801	2.12 ± 1.45	2.06 ± 1.75	0.480	2.28 ± 1.84	1.54 ± 0.7	0.303
	Mean (IQR)	1.5 (1-2.75)	1.3 (1-2)	2 (1-3)		1.35 (1-2.3)	1.6 (1-2.55)	1.5 (1-3.5)	3 (2.25-2.75)		1.7 (1-2.4)	1.5 (1-4.25)	1 (1-3)	1.5 (1-1.85)		1.7 (1-3)	1.45 (1-2.08)		2 (1-3)	1.35 (1-1.78)
Caspase TP%	Mean ± SD	2.81 ± 3.32	3.01 ± 2.6	3.11 ± 1.65	0.455	2.66 ± 2.44	2.8 ± 1.44	2.6 ± 1.92	4.5 ± 0.71	0.296	3.41 ± 2.96	2.65 ± 1.74	2.71 ± 1.38	2.36 ± 0.96	0.845	3.85 ± 3.63	2.62 ± 1.34	0.354	3.19 ± 2.65	2.52 ± 1.22	0.602
	Mean (IQR)	1 (1-4.38)	3 (1.2-3.85)	3 (2-4)		1.7 (1-4)	3 (1.9-3.55)	2 (1-4.5)	4.5 (3-4.25)		3 (1-4.5)	2.5 (1-3.18)	3 (1-4)	2.3 (1.5-3.25)		4 (1-5)	2.8 (1.5-3.5)		3 (1-4)	2.15 (1.75-3.25)

LVI: Lymphovascular Involvement, PI: Perineural Invasion, T: T stage, N: N stage.