Table 4.

Regional distribution of the tumors according to combined status of IDH and TERTp

	Number	Frontal P/N	no Frontal P/N	P (F vs. NF)	Midline P/N	no Midline P/N	P (M vs. NM)
IDH wt-TERTp wt	57	10/71	47/85	0.0002	17/4	40/152	<0.0001
IDH wt-TERTp mut	13	5/76	8/124	1.0000	2/19	7/185	0.6309
IDH mut-TERTp wt	95	41/40	54/78	0.2015	2/19	93/99	0.0004
IDH mut-TERTp mut	48	25/56	23/109	0.0281	0/21	48/144	0.0050

Abbreviations: P/N, numbers of gliomas with positive/negative biomarker mutation; P (F vs. NF), P values between Frontal and no-Frontal; P (M vs. NM), P values between Midline and no-Midline.