Table 6.
Correlations between locations distribution and molecular status of subgroups of WHO grade II and III gliomas
| Number | Frontal P/N | no Frontal P/N | P (F vs. NF) | Midline P/N | no Midline P/N | P (M vs. NM) | |
|---|---|---|---|---|---|---|---|
| II | |||||||
| TERTp | 158 | 23/38 | 22/75 | 0.0468 | 0/11 | 45/102 | 0.0346 |
| IDH1/2 | 163 | 56/6 | 67/34 | 0.0006 | 0/11 | 123/29 | <0.0001 |
| III | |||||||
| TERTp | 55 | 7/13 | 9/26 | 0.5434 | 2/8 | 14/31 | 0.7055 |
| IDH1/2 | 62 | 11/10 | 15/26 | 0.2329 | 2/8 | 24/28 | 0.3316 |
| Man | |||||||
| TERTp | 131 | 15/29 | 20/67 | 0.1750 | 2/15 | 33/81 | 0.2376 |
| IDH1/2 | 140 | 40/5 | 52/43 | <0.0001 | 2/15 | 90/33 | <0.0001 |
| Female | |||||||
| TERTP | 82 | 15/22 | 11/34 | 0.1191 | 0/4 | 26/52 | 0.3058 |
| IDH1/2 | 85 | 27/11 | 31/16 | 0.6159 | 0/4 | 58/23 | 0.0087 |
| >40 | |||||||
| TERTp | 103 | 19/25 | 17/42 | 0.130 | 2/7 | 34/60 | 0.4894 |
| IDH1/2 | 108 | 35/10 | 32/31 | 0.0051 | 1/8 | 66/33 | 0.0017 |
| ≤40 | |||||||
| TERTp | 110 | 11/26 | 14/59 | 0.2122 | 0/12 | 25/73 | 0.0646 |
| IDH1/2 | 117 | 32/6 | 50/29 | 0.0301 | 1/10 | 81/25 | <0.0001 |
Abbreviations: P/N, numbers of gliomas with positive/negative biomarker mutation; P (F vs. NF), P values between Frontal and no-Frontal; P (M vs. NM), P values between Midline and no-Midline.