Table 2.
Association between DNA gene polymorphisms and risk of pancreatic cancer
| Polymorphisms | Cases | % | Controls | % | HWE | χ2-test | P value | Adjusted OR (95% CI)1 | P value |
|---|---|---|---|---|---|---|---|---|---|
| ERCC1 rs3212986 | |||||||||
| GG | 80 | 32.52 | 105 | 42.68 | 1.0 (Ref.) | - | |||
| GT | 124 | 50.41 | 118 | 47.97 | 1.38 (0.92-2.07) | 0.10 | |||
| TT | 42 | 17.07 | 23 | 9.35 | 0.21 | 9.08 | 0.011 | 2.40 (1.29-4.52) | 0.003 |
| ERCC1 rs11615 | |||||||||
| CC | 111 | 45.12 | 120 | 48.78 | 1.0 (Ref.) | - | |||
| CT | 108 | 43.90 | 104 | 42.28 | 0.94 | 0.94 | 0.63 | 1.12 (0.76-1.66) | 0.54 |
| TT | 27 | 10.98 | 22 | 8.94 | 1.33 (0.68-2.60) | 0.37 | |||
| ERCC2 rs13181 | |||||||||
| TT | 131 | 53.25 | 159 | 64.63 | 1.0 (Ref.) | - | |||
| TG | 72 | 29.27 | 64 | 26.02 | 1.37 (0.89-2.10) | 0.13 | |||
| GG | 43 | 17.48 | 23 | 9.35 | <0.001 | 9.23 | 0.01 | 2.27 (1.26-4.15) | 0.003 |
| ERCC3 rs4150506 | |||||||||
| GG | 90 | 36.59 | 96 | 39.02 | 1.0 (Ref.) | - | |||
| GA | 115 | 46.75 | 112 | 45.53 | 1.10 (0.73-1.64) | 0.65 | |||
| AA | 41 | 16.67 | 38 | 15.45 | 0.57 | 0.32 | 0.85 | 1.15 (0.66-2.02) | 0.60 |
| ERCC4 rs6498486 | |||||||||
| AA | 125 | 50.81 | 133 | 54.07 | 1.0 (Ref.) | - | |||
| AC | 94 | 38.21 | 90 | 36.59 | 1.11 (0.75-1.65) | 0.58 | |||
| CC | 27 | 10.98 | 23 | 9.35 | 0.18 | 0.66 | 0.72 | 1.25 (0.65-2.41) | 0.47 |
| ERCC5 rs873601 | |||||||||
| GG | 105 | 42.68 | 118 | 47.97 | 1.0 (Ref.) | - | |||
| GA | 111 | 45.12 | 107 | 43.50 | 1.17 (0.79-1.72) | 0.42 | |||
| AA | 30 | 12.20 | 21 | 8.54 | 0.64 | 2.42 | 0.30 | 1.61 (0.83-3.13) | 0.13 |
| XPA rs2808668 | |||||||||
| TT | 85 | 34.55 | 95 | 38.62 | 1.0 (Ref.) | - | |||
| TC | 132 | 53.66 | 126 | 51.22 | 1.17 (0.79-1.75) | 0.42 | |||
| CC | 29 | 11.79 | 25 | 10.16 | 0.07 | 0.99 | 0.61 | 1.30 (0.67-2.50) | 0.40 |
| XPC rs2228000 | |||||||||
| CC | 119 | 48.37 | 131 | 53.25 | 1.0 (Ref.) | - | |||
| CT | 95 | 38.62 | 85 | 34.55 | 1.23 (0.82-1.84) | 0.29 | |||
| TT | 32 | 13.01 | 30 | 12.20 | <0.001 | 1.20 | 0.55 | 1.17 (0.65-2.13) | 0.57 |
| XPC rs2228001 | |||||||||
| AA | 117 | 47.56 | 127 | 51.63 | 1.0 (Ref.) | - | |||
| AC | 109 | 44.31 | 106 | 43.09 | 1.12 (0.76-1.64) | 0.56 | |||
| CC | 21 | 8.54 | 13 | 5.28 | 0.13 | 2.33 | 0.31 | 1.75 (0.79-3.99) | 0.13 |
| DDB2 rs2029298 | |||||||||
| GG | 100 | 40.65 | 112 | 45.53 | 1.0 (Ref.) | - | |||
| GA | 110 | 44.72 | 104 | 42.28 | 1.18 (0.80-1.76) | 0.38 | |||
| AA | 36 | 14.63 | 30 | 12.20 | 0.44 | 1.39 | 0.50 | 1.34 (0.74-2.44) | 0.30 |
1
Adjusted for sex, age, tobacco smoking, alcohol drinking, body mass index and family history of pancreatic cancer in the first relatives.