Table 3.

Interaction between ERCC1 rs3212986 and ERCC2 rs1318 gene polymorphisms and tobacco smoking and alcohol drinking in the risk of pancreatic cancer

	ERCC1 rs3212986				OR (95% CI)1	P value	ERCC2 rs1318				OR (95% CI)	P value
	GG		GT+TT				TT		TG+GG
	Patients	Controls	Patients	Controls			Patients	Controls	Patients	Controls
Tobacco smoking
Non-smokers	41	63	73	88	1.27 (0.75-2.17)	0.34	68	99	46	52	1.29 (0.76-2.19)	0.32
Smokers	39	42	93	53	1.89 (1.05-3.40)	0.02	63	60	69	35	1.88 (1.06-3.34)	0.02
Alcohol drinking
Non-drinkers	35	60	71	81	1.50 (0.86-2.63)	0.13	56	91	50	50	1.63 (0.94-2.81)	0.06
Drinkers	45	45	95	60	1.58 (0.91-2.77)	0.09	75	68	65	37	1.59 (0.92-2.78)	0.08

¹Adjusted for sex, age, body mass index and family history of pancreatic cancer in the first relatives.