Table 4.
Stratification analyses of the CCND1 G870A polymorphism and their associations with risk of MTX-related hepatotoxicity among high-risk and medium-risk ALL children
| Without hepatotoxicity | Hepatotoxicity | Adjusted OR (95% CI)† | P * | |
|---|---|---|---|---|
| Total | 34 | 23 | ||
| 870GG | 14 (41.1%) | 2 (8.7%) | 1 | 0.027 |
| 870AG | 11 (32.4%) | 11 (47.8%) | 8.21 (1.38-48.76) | |
| 870AA | 9 (26.5%) | 10 (43.5%) | 8.81 (1.45-53.59) | |
| 870AG/AA | 20 (58.9%) | 21 (91.3%) | 7.88 (1.53-40.57) | |
| A allele | 0.43 | 0.67 | 0.013 |
†
Adjusted for age and gender in logistic regression model.
*
Two-sided χ2 test for either genotype distributions or allele frequencies between subjects with and without MTX-related hepatotoxicity.