Table 2.
Genotype distributions of IL-17A rs2275913, rs3819025 and rs3748067 and their association with risk of coronary artery disease
| IL-17 gene | Base change | Patients | % | Controls | % | P value for HWE | OR (95% CI)1 | P value |
|---|---|---|---|---|---|---|---|---|
| rs2275913 | ||||||||
| GG | 168 | 40.48 | 220 | 49.11 | 1.0 (Ref.) | - | ||
| GA | 187 | 45.06 | 196 | 43.75 | 1.25 (0.93-1.68) | 0.12 | ||
| AA | G>A | 60 | 14.46 | 36 | 8.04 | 0.4 | 2.18 (1.35-3.56) | 0.001 |
| GA+AA | 247 | 59.52 | 232 | 51.79 | 1.39 (1.06-1.84) | 0.02 | ||
| rs3819025 | ||||||||
| AA | 179 | 43.13 | 212 | 47.32 | 1.0 (Ref.) | - | ||
| AG | 177 | 42.65 | 180 | 40.18 | 1.16 (0.86-1.57) | 0.3 | ||
| GG | A>G | 59 | 14.22 | 56 | 12.50 | 0.07 | 1.25 (0.81-1.93) | 0.29 |
| AG+GG | 236 | 56.87 | 236 | 52.68 | 1.18 (0.90-1.56) | 0.22 | ||
| rs3748067 | ||||||||
| TT | 301 | 72.53 | 339 | 75.67 | 1.0 (Ref.) | - | ||
| TC | 91 | 21.93 | 95 | 21.21 | 1.08 (0.77-1.52) | 0.65 | ||
| CC | C>T | 23 | 5.54 | 14 | 3.13 | 0.03 | 1.85 (0.89-3.96) | 0.07 |
| TC+CC | 114 | 27.47 | 109 | 24.33 | 1.18 (0.86-1.62) | 0.29 |
1
Adjusted for sex, age, hypertension, diabetes mellitus, alcohol drinking, tobacco smoking, TC, LDL-c, HDL-c and TG.