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Wnt/β-catenin signaling was responsible for TRAF4-induced tumorgenesis. The TRAF4-transfected cells were pretreated with β-catenin siRNA. Then, cell proliferation was analyzed by MTT assay (A). Moreover, β-catenin silencing on TRAF4-induced cell invasion (B) and migration (C) was also performed. *P < 0.05.
