Table 3.

Risk stratification in nonrhabdomyosarcoma soft tissue sarcoma and treatment proposal according to the Children's Oncology Group (NCT00346164)

Risk group	Factors				Proposed treatment
	Grade	Size	Stage	Initial resectability
Low	Low	Any	Nonmetastatic	Gross resection	Observation
	High	< 5 cm	Nonmetastatic	Without microscopic margins	Observation
	High	< 5 cm	Nonmetastatic	With microscopic margin	Adjuvant radiation therapy
Intermediate	High	> 5 cm	Nonmetastatic	Gross resection	Adjuvant chemotherapy and radiation therapy
	High	> 5 cm	Nonmetastatic	Unresected	Neoadjuvant chemoradiotherapy, surgery, adjuvant chemotherapy with or without radiation therapy
High	Low	Any	Metastatic	Gross resection	Observation
	High	Any	Metastatic	Gross resection	Adjuvant chemotherapy and radiation therapy
	High	Any	Metastatic	Unresected	Neoadjuvant chemoradiotherapy, surgery, adjuvant chemotherapy with or without radiation therapy