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. 2015 Nov 9;5:16548. doi: 10.1038/srep16548

Figure 6. ZO-1 and Occludin reduction induced by NaCl was depended on p38/MAPK and SGK1 signaling.

Figure 6

(A) SGK1 expression in the ischemic brain hemisphere after HSD. The bar graph shows a significant increase in HSD-treated mice compared with mice on a normal diet. (n = 5 per group; Normal vs HSD, *P < 0.05, **P < 0.01). (B) Detection of SGK1 expression in bEnd.3 cells NaCl treatments at different concentrations. The data are pooled from three independent experiments. (*P < 0.05, **P < 0.01). (C) Western blotting analysis of ZO-1 and Occludin in bEnd.3 cell after 6 h OGD in the presence or absence of NaCl, p38i or SGK-1i. The bar graphs below show the statistical analysis. (*P < 0.05, **P < 0.01, ***P < 0.001). Values are mean ± SD.