Table 3. (A) Main characteristics of the studies of the MTHFR haplotype included in the meta-analysis; (B) Main results for the MTHFR haplotype in the meta-analysis.
A | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Name | Year | Country | Ethnicity | Case | Con | CA1 | CC1 | TA1 | TC1 | CA0 | CC0 | TA0 | TC0 |
Dhillon VS | 2007 | India | Asian | 179 | 200 | 182 | 57 | 78 | 41 | 164 | 76 | 126 | 34 |
Safarinejad MR | 2011 | Iran | Asian | 164 | 328 | 165 | 31 | 55 | 77 | 336 | 100 | 103 | 117 |
Eloualid A | 2012 | Morocco | African | 257 | 690 | 305 | 89 | 92 | 28 | 801 | 319 | 252 | 8 |
Herodez SS | 2013 | Slovenia | European | 100 | 111 | 69 | 39 | 53 | 37 | 95 | 49 | 51 | 27 |
Mfady DS | 2013 | Jordan | Asian | 150 | 150 | 106 | 90 | 96 | 8 | 112 | 103 | 81 | 4 |
B | |||||||||||||
MTHFR haplotype | CC vs CA | TA vs CA | TC vs CA | CC vs TA | CC vs TC | TA vs TC | |||||||
Variables | Na | OR(95%CI) | Pb | OR(95%CI) | Pb | OR(95%CI) | Pb | OR(95%CI) | Pb | OR(95%CI) | Pb | OR(95%CI) | Pb |
Total | 5 | 0.77(0.65-0.91) | 0.420 | 0.99(0.73-1.34) | 0.008 | 2.09(1.11-3.93) | 0.000 | 0.80(0.66-0.97) | 0.281 | 0.41(0.31-0.55) | 0.001 | 0.54(0.42-0.71) | 0.001 |
Asian | 3 | 0.74(0.59-0.94) | 0.380 | 0.91(0.55-1.50) | 0.005 | 1.29(0.98-1.70) | 0.572 | 0.82(0.63-1.05) | 0.085 | 0.52(0.36-0.74) | 0.738 | 0.67(0.48-0.93) | 0.421 |
aNumber of studies.
bThe value of heterogeneity test.