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. 2015 Nov 9;5:15701. doi: 10.1038/srep15701

Figure 4. Blockade of STAT3 signaling reversed IL-6-mediated inhibition of starvation-induced autophagy.

Figure 4

(a) Immunoblot analysis of STAT3 in U937 cells treated or not with LLL12 at the indicated concentration for 30 min or DMSO as a control before incubation in culture medium. (b) Immunoblot analysis of LC3, STAT3, Beclin 1 and VPS34 in U937 cells treated or not with LLL12 (0.5 μM) or DMSO for 30 min before incubation in culture medium. (c) Immunoblot analysis of STAT3, LC3, p62, Bcl-2, Beclin 1 and VPS34 in U937 cells transiently transfected with pcDNA3.1(+) STAT3WT or pcDNA3.1(+) STAT3Y705F for 48 h before incubation in culture medium.