Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Nov 9;5:16232. doi: 10.1038/srep16232

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2015, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

PMC Copyright notice

LKB1 may regulate cerebellar foliation and development by controlling the GCP proliferation via Shh signalling, which controls the G1 cyclins during cerebellar development. In our mutant mice, LKB1 deletion significantly increased the level of Shh signalling, which may increase cyclinD1. These changes resulted in an abnormal increase in GCP proliferation, which caused the cerebellar defects and extra lobules. AMPK likely acts as a mediator between LKB1 and Shh signalling in the LKB1^Atoh1 CKO cerebellum.