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. Author manuscript; available in PMC: 2015 Nov 9.
Published in final edited form as: J Pharm Sci. 2011 Jun 30;100(11):4993–5006. doi: 10.1002/jps.22681

Fig. 7. Hemodynamic response as a function of plasma dobutamine concentration for A) max dP/dt, B) Heart rate (HR), C) systemic vascular resistance (SVR), D) Mean Arterial Preasure (MAP) and E) Stroke Volume (SV) for low.

Fig. 7

(0.5 μg/kg/min) and high (5 μg/kg/min) dose given either by EC or IV routes. Data are fit to sigmoidal curves (Prism 5.04, Graph Pad). Hemodynamic responses correlate to blood levels for IV infusion. Max dP/dt, HR and SV do not correlate with blood concentrations with local EC application, as they are dependent on drug levels within the myocardium. SVR and MAP, which can be considered peripheral effects correlate with plasma drug levels even with local application (N=7, note that some of the plasma samples were below detection limits and these data are omitted from this analysis.)