Figure 1.

Hemodynamic dose response to epinephrine IV infusions in terms of systemic vascular resistance (SVR) (Panel A) heart rate (HR) (Panel B), contractility (max dP/dt) (Panel C) and lusitropy (min dP/dt) (Panel D). Each dose produces a unique hemodynamic response. The lowest dose did not elicit any hemodynamic response. SVR was significantly lowered starting at 0.1 mcg · kg ⁻¹· min ⁻¹ and heart rate increased at 0.2 mcg · kg ⁻¹· min ⁻¹ infusion rate. Max dP/dt and min dP/dt were were first increased above baseline at 0.3 mcg · kg ⁻¹· min ⁻¹. Data are presented as log-transformed to the base of 10. N=6, AVG ± SD.

V - < 0.05 – compared with 0.00 mcg · kg ⁻¹· min ⁻¹ infusion rate,

* - < 0.05 – compared with 0.05 mcg · kg ⁻¹· min ⁻¹ infusion rate,

† - < 0.05 – compared with 0.1 mcg · kg ⁻¹· min ⁻¹ infusion rate,

‡ - < 0.05 – compared with 0.2 mcg · kg ⁻¹· min ⁻¹ infusion rate.