. Author manuscript; available in PMC: 2015 Nov 9.

Published in final edited form as: Am J Physiol Cell Physiol. 2001 Dec;281(6):C1825–C1836. doi: 10.1152/ajpcell.2001.281.6.C1825

Table 1. Influence of SIN-1 on Na⁺ and Cl⁻ dependency of taurine uptake.

	Uptake, fmol·mg protein⁻¹ ·15 min⁻¹
Buffer	−SIN-1 (control)	+SIN-1
NaCl (140 mM)	2,036.6 ± 54.9	6,898.4 ± 94.2
NaCl (140 mM) + β-alanine (2.5 mM)	94.6 ± 1.3	166.8 ± 5.9
NMDG-Cl (140 mM)	27.9 ± 1.6	23.4 ± 1.7
Sodium gluconate (140 mM)	49.3 ± 7.2	31.2 ± 3.4

Values are means ± SE. ARPE-19 cells were treated with or without 1 mM 3-morpholinosydnonimine (SIN-1) for 24 h, and uptake of [³H]taurine (80 nM) was measured. Uptake buffer consisted of 20 mM HEPES-Tris (pH 7.5) containing 140 mM NaCl, sodium gluconate, or N-methyl-d-glucamine (NMDG) chloride. Inhibition of taurine transport in the presence of β-alanine (in NaCl buffer) was also measured.

Table 1. Influence of SIN-1 on Na+ and Cl− dependency of taurine uptake.

Table 1. Influence of SIN-1 on Na⁺ and Cl⁻ dependency of taurine uptake.