Table 2.

HE4 reference range in healthy populations according to age or menopause status

	Number	Value (mean ± SD)	Reference range (2.5–97.5 %)
Ages*
<40	201	45.85 ± 10.72	29.25–68.50
40–49	102	47.80 ± 9.73	32.11–68.96
50–59	104	54,11 ± 14.30	33.04–88.67
60–69	108	59.91 ± 14.33	34.72–92.35
≥70	103	77.57 ± 23.20	45.18–132.00
Pre-menopause	308	46.61 ± 10.70	29.25–68.96
Post-menopause	310	63.94 ± 20.21	34.72–114.90
Overall	618	55.30 ± 18.35	31.82–105.10

*A statistical significant difference in HE4 was found between each age group (p < 0.0001) except between <40 and 40–49