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Copy number gains of MET and EGFR in EGFR-mutant lung cancer cell lines and their afatinib-resistant sublines. (a) The copy numbers of MET examined by real-time PCR were significantly amplified in HCC827-AR2, -AR3 and -ACR cells and slightly amplified in HCC4011-AR1 cells. (b) The copy number of EGFR in HCC827-ACR cells was approximately half of that in the parental cell line. All experiments were performed at least three times, and error bars indicate standard deviations.
