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. 2015 Sep 25;106(10):1438–1447. doi: 10.1111/cas.12756

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© 2015 The Authors. Cancer Science published by Wiley Publishing Asia Pty Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Penetration of doxorubicin (Dox) through multilayered cell cultures (MCCs) generated from EMT6 (a, c) and MCF7 (b, d) cells with and without lansoprazole (Lanso) pretreatment. Note the increased doxorubicin (Dox) fluorescence in regions more distal from the source of drug in MCCs that were pretreated with 250 μM lansoprazole (c, d) compared to controls (a, b) at 2 h following drug exposure (3.6 μM doxorubicin). (e, f) Quantitative analysis of doxorubicin as a function of distance from the drug source in EMT6- and MCF7-derived MCCs pretreated with lansoprazole in comparison with controls. Doxorubicin fluorescence intensity was quantified at 2 h after the drug was given as a function of the depth from the top of MCCs. Data are presented as the mean ± SEM. Scale bar = 100 μm.