Table 2.
Cox proportional hazards regression analysis of disease-free survival
| Variables | Univariate | Multivariate | ||
|---|---|---|---|---|
| HR (95% CI) | P-value | HR (95% CI) | P-value | |
| Age (≥70 years) | 1.03 (0.62–1.71) | 0.913 | ||
| Sex (Male) | 1.35 (0.83–2.04) | 0.244 | ||
| CA 19-9 (≥1000 U/mL) | 1.56 (0.91–2.68) | 0.104 | ||
| T stage (T3/T2,T1) | 3.2 (0.44–23.04) | 0.248 | ||
| N stage (N1/N0) | 1.81 (1.12–2.91) | 0.015 | 1.98 (1.21–3.22) | 0.006 |
| Differentiation (UD,PD/MD,WD) | 1.07 (0.53–2.15) | 0.849 | ||
| AL invasion | 1.55 (0.99–2.42) | 0.056 | ||
| VE invasion | 1.43 (0.91–2.28) | 0.124 | ||
| PN invasion | 2.12 (1.02–4.43) | 0.044 | 2.23 (1.06–4.72) | 0.036 |
| CP | 0.99 (0.60–1.64) | 0.987 | ||
| PanIN-3 | 0.93 (0.55–1.59) | 0.808 | ||
| Adjuvant therapy | 0.62 (0.39–1.00) | 0.050 | 0.62 (0.38–1.02) | 0.058 |
| PanIN-3 with CP | 2.17 (1.04–4.56) | 0.039 | 2.51 (1.15–5.46) | 0.020 |
AL, angiolymphatic; CI, confidential interval; CP, chronic pancreatitis; HR, hazard ratio; MD, moderately differentiated; PanIN, pancreatic intraepithelial neoplasia PD, poorly differentiated; PN, perineural; UD, undifferentiated; VE, venous; WD, well differentiated.