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. 2015 Nov 9;8:74. doi: 10.1186/s12920-015-0151-8

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© Maeng et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — TGFβ1 enhanced MLL1 recruitment on TGFBIp and ECM-associated gene promoters. a Total mRNA was isolated from wild-type and GCD2-homozygous corneal fibroblasts, and gene-expression profiles were assessed using an Affymetrix gene chip. The expression levels of H3K4 methyltransferase genes are presented as the log2 ratio. b, c MLL1 recruitment to the indicated gene promoters in wild-type and GCD2 corneal fibroblasts stimulated by TGFβ1 (5 ng/ml) for 8 h. MLL1 recruitment was determined by ChIP assays with MLL1 antibody. Results were normalized to the input, and MLL1 occupancy was expressed as the fold enrichment over the respective wild-type control samples (mean ± standard error (SE); **P < 0.01 vs. wild type, n = 3)