Fig. 4.
Nucleotide (A) and deduced amino add (B) sequences of the VL genes utilized by the natural human mAb. In each duster, the top sequence is given for comparison and represents the published VL gene displaying the highest degree of homotogy to the expressed VL genes of the cluster. VλIII.1 (VλIII subgroup), VλIV, and Hum1v117 (VλI subgroup) are sequences of genomic germline genes. T2:C5 (VλI subgroup) and DSC VλII are sequences rearranged, but possibly unmutated genes. Dashes ridicate identities. Solid lines on the top of each duster depict complimentarily determining regions. Small letters denote untranslated sequences. Asterisks indicate translation initiation codons. The present sequences are available from EMBL/GenBank/DDBJ under accession numbers L25295, L25296, L25297, and L25298.