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. 2015 Nov 9;6:569. doi: 10.3389/fimmu.2015.00569

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Copyright © 2015 Raker, Domogalla and Steinbrink.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Regulatory T cell subsets induced by tolerogenic DCs. Tolerogenic DCs can induce a variety of Treg populations depending on the culture conditions and the tolerogenic factor they encountered during differentiation. Repetitive stimulation of T cells with iDCs leads to anergy or Treg induction. IL-10-modulated DCs induce Tr-1 cells or CD4⁺ and CD8⁺ suppressor T cells. Vitamin D3 and corticosteroids favor the induction of CD4⁺CD25⁺Foxp3⁺ Tregs.