FIG. 2.

Gene sets related to glucocorticoid receptor processes. Gene sets from NCI’s Pathway Interaction Database, the proprietary Metacore database, and the Gene Ontology database were overlaid onto an interaction network from the STRING protein-protein interaction database (only high confidence interactions are shown, STRING combined score ≥0.9). Colored genes are unique to a particular database, while gray genes are shared between two or more databases (only NR3C1 is common to all four databases). There are clear differences in membership between gene sets from different data sources. These differences may be due to an attempt to model distinct processes, but are also indicative of incomplete annotation. For instance, some genes are unique to a single database even when there is evidence of interaction with multiple genes from another database (e.g., ARID1A is not part of the NCI-PID gene set, but is connected to four of its member genes).