Table 3.

Iron-related genes in P. mirabilis.

Gene Designation(s)	Proposed function	PMI number(s)	Upregulated in iron limitation	Upregulated in vivo	Implicated in vivo	Antigenic in vivo	Citations
Heme uptake
	TonB-dependent receptor	PMI0409	✓			✓	(45, 238)
	hemin uptake protein	PMI1424	✓	✓			(25, 238)
hmuR1R2STUV	hemin uptake system	PMI1425-1430	✓	✓	✓	✓	(25, 45, 238, 239)
Ferrous Iron Uptake
sitDCBA	Iron ABC transporter	PMI1024-1027	✓	✓			(25, 238)
feoAB	ferrus iron transport	PMI2920-2921		✓			(25)
Ferric citrate transport
	exported protease	PMI3704	✓				(238)
	iron-related ABC transporter	PMI3705	✓		✓		(57, 238)
	iron receptor	PMI3706-3707	✓				(238)
	extracytoplasmic function family σ factor	PMI3708	✓				(238)
	TonB-like protein	PMI3709	✓				(238)
Siderophore production
	TonB-dependent receptor	PMI2596	✓		✓	✓	(45, 238)
nrpXYRSUTABG	Nrp siderophore	PMI2597-2605	✓	✓	✓		(25, 56, 238)
pbtIABCDEFGH	proteobactin	PMI0231-0239	✓	✓			(57, 238)
Other TonB-dependent receptors
irgA	TonB-dependent enterobactin receptor	PMI0842	✓	✓	✓	✓	(25, 45, 238)
ireA	ferric siderophore receptor	PMI1945	✓	✓		✓	(25, 45, 238)
	TonB-dependent receptor	PMI0363	✓	✓			(25, 238)
	TonB-dependent receptor	PMI1548-1551	✓	✓			(25, 238)
hasR	TonB-dependent receptor	PMI3120-3121			✓		(56)
ABC-transport system
	iron-related ABC transporter	PMI0331		✓			(25, 238)
	iron-related ABC transporter	PMI2957-2960	✓	✓	✓		(25, 56, 238)
	Iron-related ABC transporter	PMI0229-0230					(238)
Iron Metabolism
	iron utilization protein	PMI1437	✓	✓			(25, 238)
Iron Sulfur Cluster Formation/Uptake
	iron sulfur cluster	PMI1411-1416	✓	✓			(25, 238)
	iron sulfur cluster	PMI3253	✓	✓			(25, 238)
	iron sulfur cluster	PMI0176-0172	✓	✓			(25, 238)

Iron-related genes from P. mirabils were identified by homology to other iron-related genes (17, 238). Genes identified as iron-related by homology but not identified using one of the four conditions shown were excluded. A checkmark indicates that one or more of the genes in the row were identified using the condition specified.