Table I.
Characteristics of Infants with DS Evaluated for Obstructive Sleep Apnea at the Down Syndrome Program at Riley Hospital for Children, August 2005 to December 2011
| Full Sample (n=177) | Infants with PSG (n=59) | Infants with no identified PSG (n=118) | |
|---|---|---|---|
| Mean Estimated Gestational Age (weeks) | 37.5 ± 2.1 | 37 ± 2.4 | 37.8 ± 1.9 |
| Male | n=93 | n=32 | n=61 |
| Female | n=84 | n=26 | n=58 |
| Prematurity1* | n=37 (21%) | n=18 (30%) | n=19 (16%) |
| CHD2* | n=73 (41%) | n=30 (50%) | n=43 (36%) |
| GI Abnormalities3*,** | n=102 (57%) | n=41 (69%) | n=61 (51%) |
| GERD4* | n=66 (37%) | n=29 (49%) | n=37 (31%) |
| Constipation | n=43 (24%) | n=21 (36%) | n=22 (19%) |
| Duodenal Atresia | n=10 (5%) | n=4 (7%) | n=6 (5%) |
| Duodenal Stenosis | n=3 (1%) | n=1 (2%) | n=2 (2%) |
| Tracheoesophageal Fistula | n=0 (0%) | n=0 (0%) | n=0 (0%) |
| Malrotation | n=3(1%) | n=2 (3%) | n=1 (1%) |
| Hirschsprung Disease | n=12 (7%) | n=6 (10%) | n=6 (5%) |
| Dysphagia* | n=89 (50%) | n=42 (71%) | n=47 (40%) |
Prematurity in estimated gestational age (weeks)
Congenital heart disease including atrial septal defects, ventricular septal defects, atrioventricular canal defects, tetralogy of Fallot, aortic coarctation, and patent ductus arteriosus
Includes the presence of one or more of the following structural or functional gastrointestinal abnormalities: gastroesophageal reflux disease, constipation, duodenal atresia, duodenal stenosis, tracheoesophageal fistula, malrotation, and Hirschsprung disease.
Gastroesophageal reflux disease
Denotes statistically significant correlate of obstructive sleep apnea, defined by AHI level of 2 or greater.
Denotes statistical significance of odds ratio P=0.002.