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. Author manuscript; available in PMC: 2015 Nov 9.

Published in final edited form as: Chembiochem. 2015 Aug 25;16(14):2065–2072. doi: 10.1002/cbic.201500289

Co^III-Ebox treatment alleviated the HRG-induced increase in breast cancer cell migration and invasion. Graphs comparing the percent migration of A) SKBR3 and B) MCF7 cells in a scratch wound assay in the presence and absence of HRG, and with or without Co^III-Ebox co-treatment. Data are represented as means±S.E.M., n =9. Comparison of C) the percent migration and D) the percent invasion of HRG-treated MDA-MB-231, SKBR3, and MCF7 cells with (■) or without ( ) Co^III-Ebox co-treatment, and with or without chemo-attractant (serum). Data are represented as means ± S.E.M., n =3. Student’s t-tests determined statistical significance between control and Co^III-Ebox treatment where *P<0.05 and **P <0.005.

Inline graphic — Co^III-Ebox treatment alleviated the HRG-induced increase in breast cancer cell migration and invasion. Graphs comparing the percent migration of A) SKBR3 and B) MCF7 cells in a scratch wound assay in the presence and absence of HRG, and with or without Co^III-Ebox co-treatment. Data are represented as means±S.E.M., n =9. Comparison of C) the percent migration and D) the percent invasion of HRG-treated MDA-MB-231, SKBR3, and MCF7 cells with (■) or without ( ) Co^III-Ebox co-treatment, and with or without chemo-attractant (serum). Data are represented as means ± S.E.M., n =3. Student’s t-tests determined statistical significance between control and Co^III-Ebox treatment where *P<0.05 and **P <0.005.