Figure 2.

Effect of EA on the protein levels of SIRT1 and PGC-1α in the hippocampus of SAMP8 mice was evaluated using Western blotting analyses. (A) Representative Western blotting analyses for SIRT1. (B) The protein expression of SIRT1 was significantly reduced in the Pc group compared with the Rc group. Compared with the Pc group, the protein expression of SIRT1 was significantly increased in the Pe group. (C) Representative Western blotting analyses for PGC-1α. (D) EA increased PGC-1α protein expression. β-actin was used as a reference protein. Data are expressed as the mean ±SEM (n=5 in each group). * p<0.05 versus Rc group; ^# p<0.05 versus Pc group.