Fig 2. Four Malaria Box compounds have statistically significant bilayer effects.

80 Malaria Box compounds were tested at 5 μM, the order of the compounds is A2 … A11, B2 … B11, etc. The four Malaria Box compounds that perturb the bilayer are MMV007384 (red bar, q₅ = 1.79, p<0.01), and from L to R (amber bars): N-{4-[(4-methyl-1-piperidinyl)methyl]phenyl}-1H-pyrrolo[3,2-h]quinoline-2-carboxamide, MMV020549, q₅ = 1.3, p<0.05); N-{4-[(4-ethyl-1-piperazinyl)methyl]phenyl}-1H-pyrrolo[3,2-h]quinoline-2-carboxamide, MMV020548, q₅ = 1.27, p < .05); and 2-{[1-(2,4-dimethoxyphenyl)-1H-imidazol-2-yl]sulfanyl}-N-(2,5-dimethylphenyl)acetamide MMV019258, q₅ = 1.32, p < .05). Error bars depict S.E.M. Unpaired, two-tailed t-tests were performed in comparison to control.